http://bibliotecatede.uninove.br/handle/tede/34 2026-04-10T03:09:18Z http://bibliotecatede.uninove.br/handle/tede/3949 Título: Preparo dos tecidos orofaciais envolvidos nas cirurgias de terceiros molares inferiores retidos com LED infravermelho para o controle da dor, trismo e edema: ensaio clínico, randomizado, duplo-cego, controlado Autor: Mello, Érika da Silva Primeiro orientador: Deana, Alessandro Melo Abstract: The removal of impacted lower third molars is indicated to avoid further complications such as pericoronitis and cysts. This removal can generate unwanted events such as pain, trismus and edema. For the control of these events, the preemptive use of corticosteroids, analgesics, anti-inflammatories and physiotherapy measures are recommended. Photobiomodulation has been shown to be effective in reducing pain, edema and trismus. This study evaluates the efficacy of photobiomodulation in conditioning the tissues involved in surgeries of retained lower third molars, aiming at the reduction or absence of postoperative pain, trismus and edema. A clinical trial, randomized, double-blind, and placebo control wanted to evaluate the pain, edema, and trismus in impacted lower thirty molar third surgery on preconditioning orofacial tissues with infrared LED 850nm, 08J during 80 seconds. After facial measures and 01 hour before surgery, the treatment group (n=31) was irradiated with infrared LED, and in the sham group, a similar device without radiation was used. The participants were evaluated and receive randomized treatment on the second and seventh day after surgery. The comparison between groups demonstrated a significant reduction for pain in the photobiomodulation group on the second day after surgery in relation to the placebo group (p = 0.006, Mann-Whitney), however it showed a lack of significant difference for the assessment of trismus. The evaluation of the edema showed that after 7 days of the surgery, the facial measurements were statistically equal to the pre-surgical values. In conclusion, he demonstrated that the conditioning of the orofacial tissues involved in third molar surgeries using an infrared LED with 850nm wavelength, performed one hour before the surgical procedure, showed positive results in reducing postoperative pain. Instituição: Universidade Nove de Julho Tipo do documento: Dissertação 2021-06-01T00:00:00Z http://bibliotecatede.uninove.br/handle/tede/3948 Título: Efeito da fotobiomodulação vascular como adjuvante ao tratamento da dor lombar: ensaio clínico piloto randomizado triplo cego Autor: Fernandes, Sirléia Mendes Primeiro orientador: Motta, Lara Jansiski Abstract: Low back pain (LBP) is a public health problem that directly impacts quality of life, being one of the main causes of functional disability, absenteeism from work, reduced social interaction, and high costs associated with long-term treatments, with the potential to affect the individual's mental health. Currently, the management of LBP involves the use of anti-inflammatory drugs, analgesics, physiotherapy, and, in specific cases, surgery. Recent studies indicate that Vascular Photobiomodulation (VPM), which prioritizes the irradiation of blood components, is a promising strategy, as it stimulates mitochondrial ATP (Adenosine Triphosphate) production, increasing blood oxygenation, promoting tissue repair, and exerting anti-inflammatory and analgesic effects. This study had as its primary objective to evaluate the efficacy of VPM in patients with low back pain. This was a pilot, randomized, triple-blind clinical trial. Participants were recruited through the principal investigator's contact network. Twenty individuals, aged between 18 and 65 years, presenting with complaints of low back pain lasting between the 1st and 5th week, were included in the study. Participants were randomly assigned to two groups (n=10 per group): Placebo Group (G1) and Treatment Group (G2). The treatment lasted four weeks, with two sessions per week (total of 8 sessions). Both groups received Manual Myofascial Release, lasting 15 minutes, and therapeutic mobility exercises for the lower and upper limbs and trunk. G1 was subjected to an inactive device (sham) that simulated light projection, and G2 received active MVFB application, with a wavelength of 660 nm; continuous mode; power of 100 mW; irradiated energy of 180 J per session; exposure time of 1800 seconds. Data collection included the application of the Oswestry Disability Index 2.0 and the Roland Morris Disability Questionnaire at the first and last consultations, and the Numerical Pain Scale (NPS) at all consultations before and after treatment. Data were collected and recorded in an Excel spreadsheet. For statistical analysis, the Student's t-test, adjustment to the Poisson distribution, Shapiro-Wilk test, Chi-square test, Wald multiple comparison, and repeated measures model were used. A significance level of 5% (α=0.05) was adopted for all analyses. The findings of this pilot study indicated a significant difference between the groups in the Oswestry Disability Index (p=0.0322) and the Roland Morris Disability Questionnaire (p=0.007), results that demonstrate that Vascular Photobiomodulation contributed to the improvement of the participants' functionality. In the pain analysis assessed through the NDS, no significant difference was found between the groups (p=0.1392). However, Group 2 (treatment), which started treatment with a higher average than Group 1 (placebo), showed a significant decrease in post-treatment pain scores during the initial sessions. Both groups showed a statistically significant intragroup difference in pain. Subsequent studies with a larger sample size are crucial for the validation and generalization of these preliminary findings. Instituição: Universidade Nove de Julho Tipo do documento: Dissertação 2025-11-25T00:00:00Z http://bibliotecatede.uninove.br/handle/tede/3947 Título: Terapia de fotobiomodulação no tratamento da síndrome geniturinária em mulheres pós - menopausadas com incontinência urinária de esforço: estudo clínico duplo-cego randomizando controlado Autor: Pereira, Silvia Regina dos Santos Primeiro orientador: Deana, Alessandro Melo Abstract: INTRODUCTION: Genitourinary Syndrome of Menopause (GSM), defined in 2013 by the International Society for the Study of Women’s Sexual Health (ISSWSH) and the North American Menopause Society (NAMS), encompasses a set of signs and symptoms resulting from estrogen deficiency, manifested by urinary, genital, and sexual changes. OBJECTIVE: To evaluate the effect of photobiomodulation (PBM) on reducing urinary loss in postmenopausal women with GSM. METHODS: A randomized, double-blind, placebo-controlled clinical trial involving 65 women over 50 years of age, postmenopausal, and with urinary incontinence. The study was approved by the Ethics Committee of Universidade Nove de Julho (approval no. 5.628.333). Participants were randomly allocated into two groups: Group A (n=33) underwent PBM with a diode laser applied externally to the vaginal area, while Group B (n=32, placebo) received the same procedure with the device switched off. The therapeutic protocol consisted of four weekly sessions using a DMC diode laser (808 nm), with 4 J per point, 100 mW power, power density of 510 mW/cm², and a beam area of 0.2 cm², totaling eight irradiated points, with 40 seconds per point. Outcome variables included FSFI-6 (Female Sexual Function Index – short version), ICIQ-SF (International Consultation on Incontinence Questionnaire – Short Form), menopausal symptoms, and VHI (Vaginal Health Index). In addition, vaginal temperature, pelvic floor strength measured by dynamometry, and urinary loss assessed by the 1-hour Pad Test were evaluated. Data normality was verified using the Shapiro-Wilks test. RESULTS: The PBM group showed a significant reduction in urinary loss compared with the placebo group (p=0.02155). Intragroup analysis revealed significant improvement in the PBM group (p=0.0085), but not in the placebo group (p=0.0747). No significant differences were observed between groups in pelvic floor strength or pelvic pressure (p>0.05). The ICIQ-SF indicated greater symptom reduction in the PBM group. Improvements in vaginal dryness and burning were also reported, although no relevant differences were found in sexual function between groups. CONCLUSION: PBM demonstrated significant efficacy in reducing urinary loss and improving symptoms of dryness and burning in postmenopausal women with GSM. However, no significant changes were observed in pelvic pressure, vaginal temperature, or sexual function. Overall, laser therapy appears to be a viable and non-invasive therapeutic option for specific symptoms associated with GSM. Instituição: Universidade Nove de Julho Tipo do documento: Tese 2025-06-24T00:00:00Z http://bibliotecatede.uninove.br/handle/tede/3946 Título: Efeitos da fotobiomodulação associada ao polidesoxirribonucleico em fibroblastos dérmicos humanos Autor: Bueno, Roberta Silvia Cruz Primeiro orientador: Rodrigues, Maria Fernanda Setúbal Destro Abstract: Skin aging is a multifactorial process characterized by reduced fibroblast activity, decreased collagen and elastin production, accumulation of reactive oxygen species, and disorganization of the extracellular matrix. These changes lead to loss of skin firmness, elasticity, and function, affecting both appearance and quality of life. Therefore, understanding cellular mechanisms and developing treatments capable of minimizing or reversing these deleterious effects is essential. In this context, photobiomodulation with red (R, 660 nm) and infrared (IR, 810 nm) light has emerged as a promising strategy for skin regeneration, as it can modulate key cellular processes such as proliferation, extracellular matrix synthesis, and repair of oxidative damage. In parallel, polydeoxyribonucleotide (PDRN), a low–molecular weight DNA derivative, exhibits biostimulatory properties by activating purinergic A2A receptors and inducing endogenous growth factors, positively impacting wound healing and dermal remodeling. This in vitro study evaluated the effects of red (660 nm) and infrared (810 nm) photobiomodulation and polydeoxyribonucleotide (PDRN), applied alone or in combination, on cell viability and the expression of genes related to extracellular matrix components. Human dermal fibroblasts (HFF-2 cell line) were divided into the following groups: control, PDRN 1 mg, PDRN 500 µg, red light (R), infrared light (IR), and the combinations R–PDRN 1 mg, R–PDRN 500 µg, IR–PDRN 1 mg, and IR–PDRN 500 µg. Irradiation was performed using a 660 nm LED with an energy of 8.16 J and an 810 nm LED with an energy of 10.37 J. The results demonstrated that after 24 h all groups maintained cell viability, with no evidence of cytotoxicity. At 48 and 72 h, a statistically significant difference was observed, with the IR–PDRN combination showing higher viability compared to the isolated treatment groups. Regarding extracellular matrix components, a significant increase in the expression of COL1A1, COL3A1, TGFβ, and elastin was observed in all treated groups compared with the control group. In conclusion, the findings indicate that both PDRN and infrared LED irradiation exert positive effects on human dermal fibroblasts, enhancing cell viability and the synthesis of extracellular matrix components. However, PDRN alone showed a more consistent and potent effect compared with its combinations with red or infrared light. The combined treatments did not potentiate the effects and, in some cases, reduced the cellular response. Among the light sources, none surpassed the effects of PDRN, with red light being less effective for COL3A expression and infrared light less effective for elastin expression. Instituição: Universidade Nove de Julho Tipo do documento: Dissertação 2025-11-24T00:00:00Z