Análise dos biomarcadores e capacidade funcional em crianças e adolescentes com hipertensão arterial pulmonar

Abstract

Introduction: Congenital heart defects account for nearly one-third of all major congenital anomalies. With advances in understanding, diagnosis and surgeries, there has been a significant increase in the survival of patients with congenital heart diseases. Among the long-term complications, PAH has considerable morbidity and mortality. Several clinical and laboratory markers are used to predict prognosis and survival, but the literature is not very robust in the pediatric population Objective: To analyze epidemiological data of patients with congenital heart disease and pulmonary arterial hypertension and to correlate functional capacity with pre-established markers in the literature of children and adolescents with congenital heart disease and pulmonary arterial hypertension. Methods: This is a retrospective study, with collection of anthropometric data, distance covered in the 6-minute walk test (meters), functional classification of the World Health Organization, BNP hormone and medications in use. Epidemiological variables were analyzed according to normality, in addition to the use of Spearman and Pearson correlation, when applicable. Results: The initial sample consisted of 59 patients, of which 34 were excluded for not meeting the inclusion criteria. The final sample consisted of 25 patients, of which 13 were female, with a mean age of 15.1 years (±1.25) and 12 were male, with a mean age of 16.5 years (±1. 75). The correlation between WHO-FC and 6MWT was r= 0.093, with p= 0.66 and the correlation between WHO-FC and BNP was r= 0.346, with p= 0.09. Conclusion: The present study did not found a significant correlation between functional capacity and biomarkers used for monitoring patients with PAH.