Avaliação da modulação do sistema nervoso autonômico em crianças portadoras de fibrose cística

Abstract

Cystic Fibrosis is characterized as a chronic obstructive disease with impaired lung function. The Autonomic Nervous System (ANS) has an important role in regulation of contractility of the smooth muscles of the bronchi, which is altered in pathological conditions. So the objective was to evaluate the effects of SNA in CF, through quantitative analysis of heart rate variability (HRV) in children with Cystic Fibrosis Colonized (CFC) and not Colonized (CFN) with Pseudomonas Aeruginosa. The method employed was to evaluate 16 children with Cystic Fibrosis (7 CFC vs. 9 CFN) and seven healthy children (HC). Heart rate was collected for 10 minutes at rest in the supine and upright position. HRV was analyzed by autoregressive spectral analysis. ANOVA was used to compare CFC, CFN and HG. The results showed that CFN group showed greater sympathetic modulation when compared to HC during the supine position. Spectral analysis showed values (p< 0.05) higher in sympathetic variable (LF%) in the group colonized with P. Auruginosa, LF%= 85.70% (80.64Ⱶ89.98) in CFC and 74.87% (69.55Ⱶ88.40) in HC during the supine position; There was a negative correlation between lung function with sympathetic activation in supine position in Cystic Fibrosis group (CFC + CFN). Children with CF may be characterized by sympathetic overactivity, inferring that colonized with P. Aeruginosa exhibit a modulation of the autonomic nervous system most affected, as well as a poorer lung function compared with children not colonized