Os efeitos da terapia com fotobiomodulação sistêmica em indivíduos com esclerose múltipla remitente recorrente – estudo clínico, randomizado

Abstract

Multiple sclerosis is an autoimmune disease of the central nervous system. Inflammation and oxidative stress contribute to the destruction of the breast and consequent blockage or deceleration of nerve impulses and painful symptoms. Photobiomodulation is a non-pharmacological therapy for people with chronic conditions and may have an untreated role for multiple sclerosis. Objective: To analyze IL-6, IL-10 and nitrosative stress after treatment with systemic photobiomodulation in patients with recurrent remitting multiple sclerosis. Methods: 34 participants were recruited at the UNINOVE clinic. Nitrite levels were analyzed by the Griess assay, IL-6 and IL-10 were analyzed by the ELISA. The individuals were randomized and allocated to the groups, being group (1) sublingual photobiomodulation therapy, group (2) photobiomodulation therapy in the radial artery, group (3) Control of healthy individuals, group (4) control individuals with multiple sclerosis. Results: Significant nitrite reduction after treatment in group 1 (p <0.01) was observed, and there was no decrease in group 2 (p> 0.05). In the IL-10 analysis the results show that there was a significant increase in groups 1 and 2 (p <0.01). There were no significant changes in IL-6 after treatment (p> 0.05). In addition, there was a reduction in scores on the modified scale of fatigue in group 1 (p <0.01), whereas in group 2 there were no significant results (p> 0.05.Conclusion: Treatment with FBM towards a. radial expression did not show a decrease in nitrite and fatigue levels, but it was able to positively modulate IL-10 expression. Treatment with sublingual FBM has been shown to be effective in reducing nitrite levels and increasing IL-10 expression, in addition to improving fatigue. The size and homogeneity of the sample may be a qualification to these assertions.