Eficácia da fotobiomodulação no tratamento do envelhecimento facial por utilização de LEDS vermelho e âmbar: estudo clínico, randomizado, controlado

Abstract

The skin undergoes morphological and physiological modifications with advanc- ing age of the individual. These changes can be caused by extrinsic factors such as exposure to solar radiation and poor life habits, and intrinsic factors of a ge- nomic, biochemical and cellular nature. These factors contribute to the en-vel- vance of the skin. Clinically, the skin becomes more flaccid, thicker, hyperpig- mented, and in the areas most exposed to solar radiation the early appearance of wrinkles is observed. Currently several treatments are used in the fight against aging of the skin, one of them is the use of photobiomodulation with LED. The objective of the study was to evaluate the percent reduction of periocular wrinkle volume after treatment with red and amber LEDs with each irradiated wavelength in a hemiface. The treatment was performed in 87 female participants aged 40 to 65 who presented aging II, III and IV on the Glogau scale and phototypes II, III and IV on the Fitzpatrick scale. The primary endpoint of the study was the volume of periocular wrinkles (crow's feet) measured by the device (VisioFace®). The results showed a decrease in wrinkle volume by 34% after treatment of 10 ses- sions in the two wavelengths in the periocular region, p <0.0001. Hydration in the region was measured through the equipment (Corneometer®) and did not show significant changes in the cutaneous hydration of the irradiated region after treat- ment. The viscoelasticity of the skin in the periocular region was measured through the equipment (Cutometer®) and showed improvement in skin elasticity by approximately 30% in the region after treatment (red p <0.0001 and amber p <0.05). Quality of life and self-assessment of participants were measured using the questionnaires adapted MelasQol-BP and Skindex-29, both of which showed lower dissatisfaction among participants with facial wrinkles after treatment (Me- lasQol p <0.01; Skindex p <0.05). In conclusion, this work showed that the wave- lengths used are equally effective in reducing periocular wrinkles, the participants showed less dissatisfaction with skin quality after treatment. The value of p <0.05 was considered significant.