Análise do efeito da irradiação do laser de baixa intensidade em veia poplítea e modulação de enzima geradora de óxido nítrico induzida em pacientes com trombose venosa profunda subaguda

Abstract

Venous thromboembolism (VTE) is a disease with high morbidity and mortality which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). It is an important and common condition it is characterized, by unspecific symptoms. The disease’s clinical conditional depends upon the affected veins and extension of the thrombus. The presented signs and symptoms are: pain, and muscle tenderness, which are the most frequent, leading edema, cyanosis and increased dilation of the superficial veins, also occur. The most clinical applications for diagnosis, it is the vascular ultrasound, noninvasive test and without side effects. Nitric oxide (NO) modulates inflammatory or anti - inflammatory responses, depending on cell type and stimulus, it is released further arteries than in veins. The low-level laser therapy (LLLT) exerts significant anti -inflammatory effects in the initial processes of wound healing, decreasing chemical mediators, cytokines, reduced the inflammatory cells migration and increased growth factors contribute directly to tissue cicatrization. We used two groups of patients with subacute thrombosis in femoropopliteal territory, and analyzed the effect of LLLT in relation to the diameter of femoral, popliteal, medial and lateral gastrocnemius and short saphenous veins and also through iNOS (induced nitric oxide synthase) messenger RNA expression (mRNA) in the blood before and after the laser application. The LLLT resulted in vasodilation vein medial gastrocnemius, although this effect was not observed in other veins analyzed. Messenger RNA expression (mRNA) of iNOS was found to be increased in the blood collected after the laser irradiation. Thus, we suggested that laser irradiation caused venous vasodilation and increased iNOS gene expression in patients with deep vein thrombosis.