Efeitos dos treinamentos físico contínuo e intervalado através da intensidade do shuttle walk test incremental, na capacidade funcional e na qualidade de vida em mulheres com neoplasia maligna de mama durante o tratamento de quimioterapia

Abstract

Introduction: Chemotherapy-induced cardiotoxicity reduces vascular endothelial function and increases vascular wall thickness. Endothelial dysfunctions caused by chemotherapy are associated with the development of cardiovascular diseases. Physical exercise is one of the strategies adopted to prevent and reduce the effects of antineoplastic therapy, promoting effects on cardiovascular reserve. Objective: Study 1: To compare the effects of continuous aerobic and resistance training at high intensity and resistance in women with breast cancer during chemotherapy treatment. Study 2: Conduct a systematic review and meta-analysis of randomized controlled trials in women with breast cancer, during and after chemotherapy treatment. Study 3 To evaluate endothelial function, functional capacity before and after performing high-intensity exercise. Methodology: Study 1: Randomized clinical trial. Patients diagnosed with breast cancer and undergoing chemotherapy treatment. They will be recruited and randomized into two groups: (a) Combined training (continuous aerobic + resistance); (b) Combined training (high intensity interval (IAI) + resistance). Study 2: PubMed, Cochrane and Scopus databases were searched. Adopted the PICO search strategy. Study 3: This is a non-randomized clinical trial, convenience sample, with the application of IAI physical exercise in patients with breast cancer. Results: Study 1: Protocol. Study 2: We included 4 studies with a total of 123 participants. FMD and VO2peak showed a statistically significant difference (p<0.001). Study 3: BaFMD improved significantly by 4.3% in patients receiving anthracyclines. Conclusion: Study 1: Resistance exercises associated with continuous aerobic or IAI are cardioprotective strategies. Study 2: Physical training improves vascular endothelial function and peak VO2 in cancer survivors. Study 3: HIIT improves baFMD, in addition to showing improvement in the distance traveled. Keywords: Breast cancer; High Intensity Exercise; Endothelial Function.