Reprodutibilidade da pressão arterial, rigidez arterial e modulação autonômica cardíaca em pacientes com doença de Parkinson

Abstract

Parkinson's disease (PD) is a neurodegenerative disease and presents non-motor alterations such as cardiovascular ones. The reproducibility of cardiovascular measurements in PD has not yet been investigated. Thus, we verified the reproducibility of blood pressure (BP) and cardiac autonomic modulation (MAC) in patients with PD. For this purpose, 20 male patients with PD (65±7 years old) were evaluated in three visits. Systematic error was obtained by 1way ANOVA, reliability by intraclass correlation coefficient (ICC) and agreement by BlandAltman limits of agreement. P<0.05 was considered significant. The minimum detectable difference was calculated. Heart rate (Polar V800 monitor), brachial and central blood pressure (auscultatory method and pulse wave analysis), MAC (heart rate variability) and arterial stiffness (pulse wave velocity) were obtained. There was a systematic error in the measurement of visit 1 compared to visit 2 (122±3 vs 116±4, p<0.05) of brachial and aortic systolic BP. The ICC ranged from 0.89 to 0.92 (for aortic and brachial BP), mean differences and Bland-Altman limits of agreement were lower when comparing visits 2 and 3. Regarding MAC and arterial stiffness there was a greater variation of measurements with low reliability. Regarding PWV, there was an ICC of 0.89. In conclusion, brachial and aortic BP seem to represent a reproducible measurement at rest in men with PD and the other measurements, in this study, showed a wide range of measurements, with less reproducible data.