Efeito da fotobiomodulação combinado com treinamento aeróbico em monoartrite: avaliação hemodinâmica e autonômica

Abstract

Arthritis is an autoimmune degenerative disease, caused by inflammation of the articular capsule. It is associated with muscle skeletal injuries, genetic factors, obesity and mechanical stress and represents a major public health problem worldwide. This study aims to analyze the effect of non-invasive therapies, such as low level laser therapy (LLLT) along with aerobic training, in an experimental model of induction of arthritis in the right knee of male Wistar rats. Randomly weighed animals weighing between 235 and 285g and ability to aerobic training on treadmill were divided into five groups: four groups with intra-articular injection of 1 mg zymosan in the right knee and one group with saline injection In the right knee, being control (C); Monoarthritis (MO); Monoarthritis + low intensity laser (ML); Monoarthritis + aerobic training (MT); And monoarthritis + low intensity laser + aerobic training (MTL). It was using the low intensity laser at wavelength of 660 nm; Power of 5mW; Energy density of 2.5 J / cm2, irradiation time of 20s, and area of 0.04 cm2. The aerobic training was of moderate intensity performed on a treadmill (Imbramed). After 48 hours of the last treatment session, the hemodynamic and autonomic data, the cell count and histological evaluations of the knee, the functional capacity and the weight gain of the rats were obtained. The results showed that trained animals had a lower weight gain as well as an improvement in functional capacity compared to sedentary groups. Significant decrease in mononuclear and polymorphonuclear leukocytes in the ML, MT and MTL groups was also observed in comparison to the MO group. Mean heart rate also decreased in MT and MTL groups in relation to OM. Improvement in the autonomic system of the MT and MTL groups was verified in relation to the MO group, when IP, VAR IP, AF% and ALFA index were analyzed. There was also a decrease in VAR PAS, BF PAS and BF%, which indicates less sympathetic activity for these groups. In the BF / AF ratio only the MTL group had a significant reduction. As the study conclusion, the Laser therapy combined with TA, is effective in the treatment of monoarthritis,, decreasing systemic and local disease involvement.