Alterações renais na prole de genitores submetidos à sobrecarga de frutose: papel do treinamento físico

Abstract

The objective of the study was to evaluate cardiometabolic, inflammatory and renal oxidative stress (OS) parameters in the offspring of rats submitted to fructose consumption, in addition to the role of exercise training (ET) in the offspring. Protocol 1 evaluated changes in a time course of weaning (CD and FD); 7 days (C7 and F7) and 30 days (C30 and F30) after weaning (n=7-9/time/group). There was an increase in triglycerides (TG) in FD and F30 offspring, and lower insulin sensitivity in fructose offspring at all times. There was an increase in systolic arterial pressure (SAP) in F30 offspring, SAP standard deviation (SD-SAP), SAP variance (VAR-SAP) and vascular sympathetic modulation (LF-abs) in F7 and F30 offspring. In the renal OS profile, there were increase in superoxide anion in FD and F30 offspring, in hydrogen peroxide in F7 and F30 offspring, in NADPH-oxidase in F7 offspring; and reduced antioxidant capacity in F30 offspring, and bioavailability of nitric oxide (nitrites) in offspring F7 and F30. Protocol 2 evaluated the impact of 4-week aerobic ET on 30-day fructose (FT30) offspring. ET reversed the metabolic alterations and attenuated the increase in SAP, SD-SAP, VAR-SAP and LF-abs in the FT30 offspring, reduced the TNF-α/IL-10 ratio and lipid peroxidation and increased nitrites in renal tissue. In conclusion our findings demonstrated impair in cardiometabolic, autonomic, and renal pro-oxidant profile in the offspring of fructose animals. These changes were attenuated by ET.